Author/Authors :
Mariel Marde، نويسنده , , Juan Zinczuk، نويسنده , , Mar?a I. Colombo، نويسنده , , Cristina Wasowski، نويسنده , , Haydee Viola، نويسنده , , Claudia Wolfman، نويسنده , , Jorge H. Medina، نويسنده , , Edmundo A. R?veda، نويسنده , , Alejandro C. Paladini، نويسنده ,
Abstract :
A series of halogenated/nitrated flavone compounds were synthesized. Some of the products were found to be potent central benzodiazepine receptor (BDZ-R) ligands. The structure-activity relationships (SAR) analysis of the new synthetic compounds, together with that of others already, described, indicates that substitutions at position 6 or 6 and 3ʹ in the flavone nucleus are the only ones that give rise to high affinity BDZ-R ligands.
