Author/Authors :
Shizuo Nakamura، نويسنده , , Kiyoto Goto، نويسنده , , Mitsuyoshi Kondo، نويسنده , , Shinsaku Naito، نويسنده , , Yoshiaki Tsuda، نويسنده , , Kozo Shishido، نويسنده ,
Abstract :
A practical and enantioselective total synthesis of the mercapturic acid sulfoxide 4, a metabolite of anti-inflammatory drug DUP 697 1, has been accomplished by employing the substratecontrolled diastereoselective oxidation of the sulfide 7 to the sulfoxide 8 as the key step. This led to the structure determination of 4.
