Author/Authors :
Bruno David، نويسنده , , Thierry Sévenet، نويسنده , , Odile Thoison، نويسنده , , Khalijah Awang، نويسنده , , Mary Païs، نويسنده , , Michel Wright، نويسنده , , Daniel Guénard، نويسنده ,
Abstract :
Semi-synthesis of derivatives of rhazinilam, an antitubulin compound, delineated some molecular features necessary for biological activity. In the course of this study, the formation of rhazinilam from 1,2-didehydroaspidospermidine is reexamined and a new mechanism is proposed.
