Title of article
Synthesis and evaluation of a designed inhibitor for nonactin biosynthesis in S. griseus ETH A7796
Author/Authors
Martyn J. Earle، نويسنده , , Nigel D. Priestley، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
2187
To page
2192
Abstract
A designed suicide inhibitor of a postulated, enzyme-catalyzed step in the biosynthesis of the macrotetrolide antibiotic nonactin (1) was synthesized and evaluated in vivo. The inhibitor reduced the rate of nonactin biosynthesis by over 75% while affecting neither biomass production nor the synthesis of other secondary metabolites. The role of the inhibitor in nonactin biosynthesis is discussed.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788931
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