Title of article
11,21-Bisphenyl-19-norpregnane derivatives are selective antiglucocorticoids
Author/Authors
Elizabeth R. Gebhard، نويسنده , , Pepijn H. van der Voort، نويسنده , , W. Schuts، نويسنده , , W. Schoonen، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
2229
To page
2234
Abstract
An efficient eight-step synthesis of 11,21-bisphenyl-19-norpregnane derivatives (10) starting from 19-norandrosta-4,9-diene-3,17-dione (5) is described. It is shown that specific combinations of polar substitutions on the 11- and the 21-phenylring in compounds (10) lead to selective antiglucocorticoids with relative high binding to the glucocorticoid receptor and almost negligible binding to the progesterone receptor.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788937
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