Author/Authors :
Michael J. Sofia، نويسنده , , Ramesh Kakarla، نويسنده , , Natan Kogan، نويسنده , , Richard Dulina، نويسنده , , Y. W. Hui، نويسنده , , Nicole T. Hatzenbuhler، نويسنده , , Dashan Liu، نويسنده , , Anna Chen، نويسنده , , Thomas Wagler، نويسنده ,
Abstract :
The drug transport reagent, methyl 3-β-amino-7α, 12α-di(1′α-glucosyl)-5β-cholate (TC002) 1 was prepared in 15% overall yield from pentaacetyl glucose and methyl cholate. Pentaacetyl glucose was converted to glucosyl sulfoxide 2 in 56% overall yield. Methyl cholate was converted to methyl 3-β-azido cholate 3 in 67% yield. Bis-glycosylation of 3 with 2 followed by a single step reduction provided 1.
