A conformational study of ligands for omega modulatory sites of GABA receptors by NOESY NMR spectroscopy and distance geometry

Conformational analysis by NOESY NMR spectroscopy and Distance Geometry of an ω1 selective (zolpidem) and a non selective (saripidem) ligand of ω modulatory sites suggests that the single set of conformations observed with zolpidem could be account for its ω1 selective properties. The methodology applied in this study appears to be a powerful technique to explore conformational space of non-peptidic ligands of GABA receptor subtypes.