Author/Authors :
Yue-Zhong Shu، نويسنده , , Qingmei Ye، نويسنده , , Hui Li، نويسنده , , Kathleen F. Kadow، نويسنده , , Raouf A. Hussain، نويسنده , , Stella Huang، نويسنده , , Donald R. Gustavson، نويسنده , , Susan E. Lowe، نويسنده , , Li-Ping Chang، نويسنده , , Dolores M. Pirnik، نويسنده , , Krishna Kodukula، نويسنده ,
Abstract :
Orevactaene (1), a novel oxopolyene, was isolated from Epicoccum nigrum WC47880 during the screening of microbial fermentation extracts for their ability to inhibit the binding between HIV-1 regulatory protein Rev and its viral RNA-binding site, Rev response element (RRE). The structure of 1 was elucidated by spectroscopic methods. Compound 1 displayed inhibitory activity against the Rev/RRE binding with an IC50 value of 3.6 μM.
