Title of article
Orevactaene,1 a novel binding inhibitor of HIV-1 rev protein to Rev response element (RRE) from Epicoccum nigrum WC47880
Author/Authors
Yue-Zhong Shu، نويسنده , , Qingmei Ye، نويسنده , , Hui Li، نويسنده , , Kathleen F. Kadow، نويسنده , , Raouf A. Hussain، نويسنده , , Stella Huang، نويسنده , , Donald R. Gustavson، نويسنده , , Susan E. Lowe، نويسنده , , Li-Ping Chang، نويسنده , , Dolores M. Pirnik، نويسنده , , Krishna Kodukula، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
4
From page
2295
To page
2298
Abstract
Orevactaene (1), a novel oxopolyene, was isolated from Epicoccum nigrum WC47880 during the screening of microbial fermentation extracts for their ability to inhibit the binding between HIV-1 regulatory protein Rev and its viral RNA-binding site, Rev response element (RRE). The structure of 1 was elucidated by spectroscopic methods. Compound 1 displayed inhibitory activity against the Rev/RRE binding with an IC50 value of 3.6 μM.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788950
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