Author/Authors :
Mark Overhand، نويسنده , , Elsbet Pieterman، نويسنده , , Louis H. Cohen، نويسنده , , A. Rob P. M. Valentijn، نويسنده , , Gijs A. van der Marel، نويسنده , , Jacques H. van Boom، نويسنده ,
Abstract :
Novel mono- and difarnesylated triphosphonates (i.e. 2 and 7) and the corresponding cyclic derivatives (i.e. 3 and 8) were synthesised and tested on inhibitory potential and specificity for the enzymes squalene synthase and protein:farnesyl transferase. The IC50 values of these new derivatives are in the range of 1–60 μM concentration.
