Title of article
Synthesis of triphosphonate analogues of farnesyl pyrophosphate. Inhibitors of squalene synthase and protein:farnesyl transferase
Author/Authors
Mark Overhand، نويسنده , , Elsbet Pieterman، نويسنده , , Louis H. Cohen، نويسنده , , A. Rob P. M. Valentijn، نويسنده , , Gijs A. van der Marel، نويسنده , , Jacques H. van Boom، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
2435
To page
2440
Abstract
Novel mono- and difarnesylated triphosphonates (i.e. 2 and 7) and the corresponding cyclic derivatives (i.e. 3 and 8) were synthesised and tested on inhibitory potential and specificity for the enzymes squalene synthase and protein:farnesyl transferase. The IC50 values of these new derivatives are in the range of 1–60 μM concentration.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788977
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