Title of article
Asymmetric synthesis of a conformationally constrained N-phosphonoalkyl dipeptide
Author/Authors
Qian Wang، نويسنده , , Bruno Pfeiffer، نويسنده , , Gordon C. Tucker، نويسنده , , Jacques Royer، نويسنده , , Henri-Philippe Husson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
4
From page
2477
To page
2480
Abstract
An asymmetric synthesis has been developed to prepare a phosphono-protected (2S,6R)-6-phosphono-piperidine-2-carboxylic acid and its (2R, 6S) isomer. Coupling qith tryptophan derivative afforded conformationally constrained N-phosphonoalkyl dipeptides (S,S,R)-2 and (S,R,S)-14 which have been both evaluated as human matrix metalloprotease inhibitors.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788986
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