Title of article
Design and synthesis of an α-mannosyl terpenoid as selective inhibitor of P-selectin
Author/Authors
Tsuyoshi Ikeda، نويسنده , , Tetsuya Kajimoto، نويسنده , , Hirosato Kondo، نويسنده , , Chi-Huey Wong، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
2485
To page
2490
Abstract
In an effort to develop the structural and functional mimics of the tetrasaccharide sialyl Lewis × as selective inhibitors of P-selectin, we have designed a mannosyl terpenoid derivative that selectively inhibits P-selectin with an IC50 value of 60 μM, but exhibits no inhibition activity against E- and L-selectins.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788988
Link To Document