Design and synthesis of an α-mannosyl terpenoid as selective inhibitor of P-selectin

In an effort to develop the structural and functional mimics of the tetrasaccharide sialyl Lewis × as selective inhibitors of P-selectin, we have designed a mannosyl terpenoid derivative that selectively inhibits P-selectin with an IC50 value of 60 μM, but exhibits no inhibition activity against E- and L-selectins.