Title of article :
Synthesis and progesterone receptor binding affinity of substituted 1-phenyl-7-benzyl-4,5,6,7-tetrahydro-1 -indazoles
Author/Authors :
Peter J. Connolly، نويسنده , , Steven K. Wetter، نويسنده , , Kimberly N. Beers، نويسنده , , Stephanie C. Hamel، نويسنده , , Donna Haynes-Johnson، نويسنده , , Margaret Kiddoe، نويسنده , , Pat Kraft، نويسنده , , Muh Tsann Lai، نويسنده , , Carolyn Campen، نويسنده , , Stephen Palmer، نويسنده , , Audrey Phillips، نويسنده ,
Abstract :
Research directed toward the discovery of non-steroidal ligands for steroid receptors led to the preparation of a series of substituted 1-phenyl-7-benzyltetrahydroindazole-3-carboxaldehydes. Appropriately substituted 3-formyl analogs (4) were found to bind with high affinity to progesterone receptors and showed agonist activity in human T47D cells but were inactive in several in vivo models for progestational activity.
