Author/Authors :
Piero Valenti، نويسنده , , Angela Rampa، نويسنده , , Alessandra Bisi، نويسنده , , Vincenza Andrisano، نويسنده , , Vanni Cavrini، نويسنده , , Lorena Fin، نويسنده , , Alessandro Buriani، نويسنده , , Piero Giusti، نويسنده ,
Abstract :
Analogues of tacrine were synthesized and evaluated for acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory activity. Compound 2a was the most potent inhibitor of AChE with a higher selectivity than tacrine for AChE over BuChE. Tacrine, on the other hand, showed the opposite behaviour with a weaker inhibitory effect on AChE than on BuChe. The compounds displayed correlated activities in isolated enzymes as well as in rat brain homogenates.
