Title of article
Synthesis and evaluation of the hybrid molecules possessing DNA-cleaving activity
Author/Authors
Kozo Shishido، نويسنده , , Shigenori Haruna، نويسنده , , Chisato Yamamura، نويسنده , , Hiromi Iitsuka، نويسنده , , Hisao Nemoto، نويسنده , , Yasuo Shinohara، نويسنده , , Masayuki Shibuya، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
2617
To page
2622
Abstract
The design and synthesis of enantiomerically enriched hybrid molecules, 1a–c and 2a–c, have been accomplished by employing the lipase-mediated asymmetric acetylation of prochiral diol 9 as the key step. Evaluation of their DNA-cleaving activity has revealed the unnatural type of enantiomer 2a-c to be more potent than 1a-c with natural configuration.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789014
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