Solid-phase synthesis of a N-carboxyalkyl tripeptide combinatorial library

A combinatorial library of N-carboxyalkyl tripeptides was prepared to generate new leads against metalloproteinases. Using the base labile TentaGel S HMB resin, an Fmoc strategy was employed to yield 100 mixtures of 200 compounds each of the general structure 5. A synthetic protocol combining both mix and split and indexed combinatorial strategies was used, and selected inhibition data against MMP-3 is reported.