Title of article
Quinine analogs as non-peptide calcitonin gene-related peptide (CGRP) receptor antagonists
Author/Authors
Robert A. Daines، نويسنده , , Kelvin K. C. Sham، نويسنده , , Jack J. Taggart، نويسنده , , William D. Kingsbury، نويسنده , , James Chan، نويسنده , , Ann Breen، نويسنده , , Jyoti Disa، نويسنده , , Nambi Aiyar، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
4
From page
2673
To page
2676
Abstract
A high-throughput screen identified quinine analog 1 as an antagonist of the human calcitonin generelated peptide (hCGRP) receptor. Thus, compound 1 displaces [125I]-CGRP from the hCGRP receptor and inhibits CGRP-mediated cAMP production with IC50 values of 5.9 ± 1.2 μM and 26 ± 5 μM, respectively. A limited structure-activity study of 1 is described.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789025
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