Title of article
The first colchicine analogue with an eight membered B-ring. Structure, optical resolution and inhibition of microtubule assembly
Author/Authors
Ulf Berg، نويسنده , , H?kan Bladh، نويسنده , , Christer Svensson، نويسنده , , Margareta Wallin، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
2771
To page
2776
Abstract
Synthesis, crystal structure, enantiomeric resolution, and CD spectroscopy of the first colchicine derivative with an eight-membered B-ring lactam obtained via a Beckmann reaction, is described and only one of the stable atropisomeric enantiomers arrests microtubule assembly.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789043
Link To Document