Author/Authors :
Roy J. Vaz، نويسنده , , George D. Maynard، نويسنده , , Elizabeth M. Kudlacz، نويسنده , , Larry D. Bratton، نويسنده , , John M. Kane، نويسنده , , Scott A. Shatzer، نويسنده , , Robert W. Knippenberg، نويسنده ,
Abstract :
Support for the conformation used in the design of a series of 4-(1H-benzimidazole-2-carbonyl)piperidines with dual histamine H1/tachykinin NK1 receptor antagonist activity has been presented. Comparative Molecular Field Analysis(CoMFA) for both receptor binding affinites of the series as well as overlays with several crystal structures of selective receptor antagonists support the conformation.
