Title of article
Simple cis-epoxide-based inhibitors of HIV-1 protease
Author/Authors
Andrew D. Abell، نويسنده , , Deborah A. Hoult، نويسنده , , Douglas A. Bergman، نويسنده , , David P. Fairlie، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
4
From page
2853
To page
2856
Abstract
The 4-nitrophenoxy-based epoxide 6a, conveniently synthesized using Sharpless epoxidation chemistry, has been shown to be an irreversible inhibitor of HIV-1 protease (Kinact 1.8 μM, pH 6.5, I = 0.1 M). Related analogues, differing in the mode of attachment to the epoxide core, have also been prepared and assayed against HIV-1 protease.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789058
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