Title of article
Non-peptide itam mimics as ZAP-70 antagonists
Author/Authors
Laszlo Revesz، نويسنده , , Ernst Blum، نويسنده , , Ute Manning، نويسنده , , B. Jachez Demange، نويسنده , , Armin Widmer، نويسنده , , Jean-François Zuber، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
4
From page
2875
To page
2878
Abstract
Non-peptide bidentate ITAM mimics as ZAP-70 antagonists have been prepared by accommodating non-hydrolyzable phosphotyrosine analogues at each end of a non-peptide spacer with a maximal P-P distance of 39 Å. The most potent antagonist 5 had an IC50=0.25μM against ZAP-70 with good cellular activity. Monodentates were ca. 10-fold weaker antagonists with improved cell permeability.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789063
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