Author/Authors :
Gregory E. Agoston، نويسنده , , Roxanne Vaughan، نويسنده , , John R. Lever، نويسنده , , Sari Izenwasser، نويسنده , , Phyllis D. Terry، نويسنده , , Amy Hauck Newman، نويسنده ,
Abstract :
A novel photoaffinity label for the dopamine transporter (DAT) based on N-substituted 3α-[bis(4′-fluorophenyl)methoxy]tropane has been synthesized in five steps and has been characterized. Preliminary binding studies indicated this ligand bound irreversibly to the dopamine transporter. Preparation of the 125I analog and its photoactivation in the presence of membrane bound DAT demonstrated it covalently binds to the DAT.
