Title of article
Novel cyanoguanidines with potent oral antitumour activity
Author/Authors
Charlotte Schou، نويسنده , , Erik R. Ottosen، نويسنده , , Hans J?rgen Petersen، نويسنده , , Fredrik Bj?rkling، نويسنده , , Scilla Latini، نويسنده , , Pernille V. Hjarnaa، نويسنده , , Erik Bramm، نويسنده , , Mona-Lise Binderup، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
3095
To page
3100
Abstract
4-Pyridyl cyanoguanidines with hydrophobic aromatic side chains showed potent antiproliferative activity in the human breast and lung cancer cell lines MCF-7, NYH and H460. In vivo, treatment with N-(6-chlorophenoxyhexyl)-N′-cyano-N″-4-pyridylguanidine (18, 20 mg/kg/day po.), gave a complete remission of tumours in a model of NYH inoculated nude mice.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789106
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