Title of article
Ester prodrugs of ampicillin tailored for intracellular accumulation
Author/Authors
Fan H. -J.، نويسنده , , Paternotte I.، نويسنده , , Vermander M.، نويسنده , , Li K.، نويسنده , , Beaujean M.، نويسنده , , Scorneaux B.، نويسنده , , Dumont P.، نويسنده , , Osinski P.، نويسنده , , Claesen M.، نويسنده , , Tulkens P. M.، نويسنده , , Sonveaux E.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
3107
To page
3112
Abstract
Seven new ester prodrugs of ampicillin with hydrolysis half-lives ranging from 65 to 308 min were synthesized. The cellular accumulation of two of them (in J774 mouse macrophages) and their activities against intracellular Staphylococcus aureus were determined in comparison with the pivaloyloxymethylester of ampicillin (pivampicillin) and ampicillin. The esters accumulated extensively and were more active than ampicillin in this in vitro system.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789108
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