Title of article :
Discovery of anti-influenza A virus activity of a corynanthe-type indole alkaloid, hirsutine, in vitro and the structure-activity relationship of natural and synthetic analogs
Author/Authors :
Hiromitsu Takayama، نويسنده , , Yasuo Iimura، نويسنده , , Mariko Kitajima، نويسنده , , Norio Aimi، نويسنده , , Kenji Konno، نويسنده , , Hiroshi Inoue، نويسنده , , Masatoshi Fujiwara، نويسنده , , Tadashi Mizuta، نويسنده , , Tomoyuki Yokota، نويسنده , , Shiro Shigeta، نويسنده , , Kenji Tokuhisa، نويسنده , , Yasuaki Hanasaki، نويسنده , , Kimio Katsuura، نويسنده ,
Abstract :
An indole alkaloid, hirsutine (1), was found to exhibit potent inhibitory effect against influenza A virus in vitro, and the essential structural feature for revealing the activity was elucidated by study of the structure-activity relationship using natural and synthetic derivatives of 1.
