Novel oligodeoxyribonucleotides incorporating L-related isodeoxynucleosides: Solid phase synthesis, enzymology, and CD studies

The synthesis of self-complementary oligodeoxyribonucleotides incorporating the L-related isodeoxynucleosides, isodA, (1) and/or isodT (4) is described. These novel oligomers exhibit high resistance towards exonucleases. Temperature- and concentration-dependent CD spectra and thermodynamic data of the oligomers show that isodA-isodT base pairs participate in duplex stabilization.