Thermal atropisomerism of fully functionalized vancomycin CD, DE, and CDE ring systems

A study of the thermal atropisomerism of fully functionalized vancomycin CD, DE and CDE ring systems is detailed. The studies suggested and resulted in the realization of a selective DE ring system atropisomerism of a fully functionalized vancomycin CDE ring system, offering a unique solution to the control of natural product atropisomer stereochemistry.