Title of article
5-aminomethylquinoxaline-2,3-diones. Part I: A novel class of AMPA receptor antagonists
Author/Authors
Yves P. Auberson، نويسنده , , Serge Bischoff، نويسنده , , Robert Moretti، نويسنده , , Markus Schmutz، نويسنده , , Siem J. Veenstra، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
65
To page
70
Abstract
A series of 5-aminomethylquinoxaline-2,3-diones have been identified as potent and selective AMPA antagonists. Some of these compounds are also active at the glycine-binding site of the NMDA receptors. A number of these novel, water-soluble quinoxaline-2,3-dione derivatives display protective effects in the electroshock-induced convulsion model in mice.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789180
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