Author/Authors :
Takashi Ogino، نويسنده , , Kiyoshi Tsuji، نويسنده , , Takashi Tojo، نويسنده , , Norihiro Igari، نويسنده , , Nobuo Seki، نويسنده , , Yu Sudo، نويسنده , , Toshitaka Manda، نويسنده , , Fusako Nishigaki، نويسنده , , Masaaki Matsuo، نويسنده ,
Abstract :
A series of dapsone-related 4-aminophenyl and 2-aminothiazolyl derivatives was prepared, and their antinephritic activity and blood toxicity were evaluated. 5-(2-Pyridylsulfonyl)-2-thiazolamine (FR115092, 26) was effective against two nephritis models, namely graft-versus-host disease (GVHD) and autoimmune W/BF1 mice, and showed none of the blood toxicity observed with dapsone.
