Author/Authors :
Wei-Min Dai، نويسنده , , Quan Li، نويسنده , , Kin Chiu Fong، نويسنده , , Chun Wo Chow، نويسنده , , Guo-ling Zhou، نويسنده , , Wataru Hamaguchi، نويسنده , , Sei-ichi Nishimoto، نويسنده ,
Abstract :
A number of novel propargylic sulfone conjugates 3 and 4 with intercalating moieties were synthesized and evaluated for DNA cleavage activity through nucleic base alkylation. A remarkable enhancement in DNA cleaving potency was observed with those conjugates 3 possessing a suitable spacer, a right attachment point at the aromatic ring, and a good intercalator.
