Title of article :
Inhibitors of Acyl-CoA:Cholesterol O-acyltransferase (ACAT) as hypocholesterolemic agents: Synthesis and structure-activity relationships of novel series of sulfonamides, acylphosphonamides and acylphosphoramidates
Author/Authors :
H. T. Lee، نويسنده , , W. H. Roark، نويسنده , , J. A. Picard، نويسنده , , D. R. Sliskovic، نويسنده , , B. D. Roth، نويسنده , , R. L. Stanfield، نويسنده , , K. L. Hamelehle، نويسنده , , R. F. Bousley، نويسنده , , B. R. Krause، نويسنده ,
Abstract :
Sulfoacetic acid, phosphoramidate, and phosphonamide analogs of the ACAT inhibitors, CI-999 and CI-1011 were synthesized. The structure-activity relationships of these compounds as ACAT inhibitors are described.
