Author/Authors :
Julian Adams، نويسنده , , Mark Behnke، نويسنده , , Shaowu Chen، نويسنده , , Amy A. Cruickshank، نويسنده , , Lawrence R. Dick، نويسنده , , Louis Grenier، نويسنده , , Janice M. Klunder، نويسنده , , Yu-Ting Ma، نويسنده , , Louis Plamondon، نويسنده , , Ross L. ، نويسنده ,
Abstract :
Potent and selective dipeptidyl boronic acid proteasome inhibitors are described. As compared to peptidyl aldehyde compounds, boronic acids in this series display dramatically enhanced potency. Compounds such as 15 are promising new therapeutics for treatment of cancer and inflammatory diseases.
