Heteroatom-substitution as a strategy for increasing the potency of competitive NMDA antagonists
Author/Authors :
Paul L. Ornstein، نويسنده , , M. Brian Arnold، نويسنده , , William H. W. Lunn، نويسنده , , Lawrence J. Heinz، نويسنده , , J. David Leander، نويسنده , , David Lodge، نويسنده , , Darryle D. Schoepp، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1998
Pages :
6
From page :
389
To page :
394
Abstract :
We report the synthesis and characterization of compounds that are competitive NMDA receptor antagonists. Significant increases in affinity and potency were obtained by incorporation of a heteroatom into the substructure of the tetrazole-substituted amino acid LY233053.
