Quaternary substituted PDE IV inhibitors II: The synthesis and in vitro evaluation of a novel series of γ-lactams
Author/Authors :
Christopher Hulme، نويسنده , , Kevin Moriarty، نويسنده , , Fu-Chih Huang، نويسنده , , Jonathon Mason، نويسنده , , Dan McGarry، نويسنده , , Richard Labaudiniere، نويسنده , , John Souness، نويسنده , , Stevan Djuric، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1998
Pages :
6
From page :
399
To page :
404
Abstract :
This communication describes the synthesis and in vitro evaluation of a novel potent series of phosphodiesterase type (IV) (PDE IV) inhibitors. Several of the quaternary substituted lactams presented possess low nanomolar IC50ʹs for PDE IV inhibition.
