Author/Authors :
Kiyoshi Nakayama، نويسنده , , Hirofumi Terasawa، نويسنده , , Ikuo Mitsui، نويسنده , , Satoru Ohsuki، نويسنده , , Kouichi Uoto، نويسنده , , Shin Iimura، نويسنده , , Tsunehiko Soga، نويسنده ,
Abstract :
An alkylation method of docetaxel at the C-10 position has been established by a radical coupling reaction using a 10-xanthate derivative of 7-O-TES-10-deacetylbaccatin III and appropriate alkenes. In addition the cytotoxic activity of 10-alkylated docetaxel analogs was evaluated. Among these analogs, a derivative having a methoxycarbonyl group at the end of the alkyl moiety exhibited more potent cytotoxic activity than docetaxel.
