Author/Authors :
Nobutoshi Murakami، نويسنده , , Takashi Umezome، نويسنده , , Taifo Mahmud، نويسنده , , Masanori Sugimoto، نويسنده , , Motomasa Kobayashi، نويسنده , , Yusuke Wataya، نويسنده , , Hye Sook Kim، نويسنده ,
Abstract :
Several O-acylated derivatives of bruceolide (2) were synthesized and their anti-malarial activities together with selective toxicities were examined. It was found that 3,15-di-O-acetyl- (3c), 3,15-di-O-propionyl- (3d) and 15-O-propionylbruceolide (3b), as well as bruceine B (3a), exhibited potent anti-malarial activities with high selective toxicities.
