Title of article
New bronchodilators selected by molecular topology
Author/Authors
I. R?os-Santamarina، نويسنده , , R. Garc?a-Domenech، نويسنده , , J. G?lvez، نويسنده , , J. Cortijo، نويسنده , , P. Santamaria and، نويسنده , , E. Morcillo، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
477
To page
482
Abstract
Molecular topology has been applied to find new lead compounds with bronchodilator activity. Among the selected compounds stands out 3-(1H-tetrazol-5yl)-9H-thioxanthene-9-one-10,10-dioxide, anthrarobin, 9-oxo-9H-thioxantene-3-carboxylic-10,10-dioxide acid, acenocoumarol and griseofulvin, with a percentage of relaxation, at 0.1 mM, of 91, 92, 85, 69 and 74 %, respectively. Theophylline shows a correspondent value of 77% (Emax=100% at 1 mM).
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789265
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