Title of article
2′-Deoxy-2′(S)-ethinyl oligonucleotides: A modification which selectively stabilizes oligoadenylate pairing to DNA complements
Author/Authors
Rolf Buff، نويسنده , , Jürg Hunziker، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
4
From page
521
To page
524
Abstract
Oligonucleotides consisting of 2′-deoxy-2′(S)-ethinyl-thymidine, -uridine, and -adenosine have been prepared. Whereas the modified pyrimidine oligonucleotides uniformly lead to weaker pairing affinity with DNA and RNA complements, the corresponding adenine oligonucleotides show enhanced thermal stability in duplexes with complementary DNA and decreased stability with RNA.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789273
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