Author/Authors :
Howard D. Beall، نويسنده , , Anna R. Hudnott، نويسنده , , Shannon Winski، نويسنده , , David Siegel، نويسنده , , Elizabeth Swann، نويسنده , , David Ross، نويسنده , , Christopher J. Moody، نويسنده ,
Abstract :
A series of indolequinones bearing various functional groups has been synthesized, and the effects of substituents on the metabolism of the quinones by recombinant human NAD(P)H:quinone oxidoreductase (NQO1), and on the toxicity toward nonsmall cell lung cancer cells with either high NQO1 activity (H460) or with no detectable activity (H596) were studied.
