Title of article
Synthesis and 5α-reductase inhibitory activities of benzofuran derivatives with a carbamoyl group
Author/Authors
Koki Ishibashi، نويسنده , , Katsuyoshi Nakajima، نويسنده , , Yuki Sugioka، نويسنده , , Mitsuo Sugiyama، نويسنده , , Takakazu Hamada، نويسنده , , Hiroyoshi Horikoshi، نويسنده , , Takahide Nishi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
561
To page
566
Abstract
A series of 2-phenylbenzofuran derivatives with a diphenylmethylcarbamoyl group at the 5 or 6 position of the benzofuran ring were synthesized and evaluated for rat and human testosterone 5α-reductase inhibitory activities in vitro. They had inhibitory activities against both enzymes and the 6-carbamoyl derivatives tended to be more potent than the 5-carbamoyl compounds.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789281
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