Author/Authors :
Ramesh Padmanabha، نويسنده , , Yue-Zhong Shu، نويسنده , , Lynda S. Cook، نويسنده , , Judy A. Veitch، نويسنده , , Marcella Donovan، نويسنده , , Susan Lowe، نويسنده , , Stella Huang، نويسنده , , Dolores Pirnik، نويسنده , , Susan P. Manly، نويسنده ,
Abstract :
A high-throughput screen was developed and implemented to identify inhibitors of the Lck tyrosine kinase. This report describes the identification of a specific inhibitor of this enzyme from the solid fermentation culture of the Penicillium sp., WC75209. The active compound was isolated and structurally characterized as 1-methoxy-5R10S-agroclavine, a new member of the ergot alkaloid family.
