Author/Authors :
Masaaki Sawa، نويسنده , , Yasuhiro Imaeda، نويسنده , , Jun Hiratake، نويسنده , , Ryota Fujii، نويسنده , , Ritsuko Umeshita، نويسنده , , Mitsuo Watanabe، نويسنده , , Hitoshi Kondo، نويسنده , , Junichi Oda، نويسنده ,
Abstract :
Hapten 4 was synthesized to generate catalytic antibodies triggering chemiluminescence by catalyzing the decomposition of the 1,2-dioxetane 3. The hapten 4 was so designed as to elicit a negatively charged functional group in the antibody combining site to catalyze the β-elimination of the protecting group in 3 as well as to lock the protecting group into an energetically favorable anti-periplanar conformation.
