Author/Authors :
Colin Bright، نويسنده , , Thomas J. Brown، نويسنده , , Paul Cox، نويسنده , , Frank Halley، نويسنده , , Peter Lockey، نويسنده , , Iain M. McLay، نويسنده , , Una Moore، نويسنده , , Barry Porter، نويسنده , , Robert J. Williams، نويسنده ,
Abstract :
A series of phenothiazines demonstrating inhibition of RANTES binding to THP-1 cell membranes has been identified. The lead compound RP23618 (IC50=3μM) was found to inhibit specific binding of 125I-RANTES, but not 125I-MCP-1 to THP-1 cell membranes and furthermore to antagonise RANTES, but not MCP-1-induced chemotaxis of THP-1 cells
