Title of article :
Peptidyl human heart chymase inhibitors. 1. Synthesis and inhibitory activity of difluoromethylene ketone derivatives bearing P′ binding subsites
Author/Authors :
Masahiro Eda، نويسنده , , Atsuyuki Ashimori، نويسنده , , Fumihiko Akahoshi، نويسنده , , Takuya Yoshimura، نويسنده , , Yoshihisa Inoue، نويسنده , , Chikara Fukaya، نويسنده , , Masahide Nakajima، نويسنده , , Hajime Fukuyama، نويسنده , , Teruaki Imada، نويسنده , , Norifumi Nakamura، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1998
Pages :
6
From page :
913
To page :
918
Abstract :
Peptidyl difluoromethylene ketone derivatives were designed to take advantage of probable additional interactions with the S′ subsite of human heart chymase. They showed potent inhibitory activities against human heart chymase and were more efficient than bovine chymotrypsin.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
1998
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
789347
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=789347
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