Oligoribonucleotides containing 8-oxo-7,8-dihydro-guanosine and 8-oxo-7,8-dihydro-2′-O-methylguanosine: Synthesis and base pairing properties

7,8-Dihydroguanosine(8-oxoG) and 7,8-dihydro-2′-O-methylguanosine(8-oxoG-Me) were chemically synthesized. Oligoribonucleotides which contain 8-oxoG or 8-oxoG-Me were synthesized. Incorporation of nucleotides opposite 8-oxoG and 8-oxoG-Me with dNTP by MMLV reverse transcriptase during cDNA synthesis was characterized