Title of article
Synthesis and SAR of a novel, potent and structurally simple LTD4 antagonist of the quinoline class
Author/Authors
Andreas von Sprecher، نويسنده , , Marc Gerspacher، نويسنده , , Andreas Beck، نويسنده , , Sabine Kimmel، نويسنده , , Hansruedi Wiestner، نويسنده , , Gary P. Anderson، نويسنده , , Ulrich Niederhauser، نويسنده , , Natarajan Subramanian، نويسنده , , Michael A. Bray، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
965
To page
970
Abstract
The two geminal ethyl groups in the succinic acid moiety of CGP57698 (4-[3-(7-fluoro-2-quinolinyl-methoxy)phenyl-amino]-2,2-diethyl-4-oxo-butanoic acid) are responsible for the high in vitro and in vivo potency of this peptidoleukotriene antagonist of the quinoline type. The synthesis and structure activity relationships of CGP57698 and its analogs are described.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789357
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