Title of article
7,8-Methylenedioxy-4H-2,3-benzodiazepin-4-ones as novel AMPA receptor antagonists
Author/Authors
Angela De Sarro، نويسنده , , Giovanbattista De Sarro، نويسنده , , Rosaria Gitto، نويسنده , , Silvana Grasso، نويسنده , , Nicola Micale، نويسنده , , Silvana Quartarone، نويسنده , , Maria Zappalà، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
971
To page
976
Abstract
The synthesis and anticonvulsant activity of novel 7,8-methylenedioxy-4H-2,3-benzodiazepin-4-ones 3a-e, structurally-related to GYKI 52466 1, a well-known noncompetitive AMPA-receptor antagonist, are reported. The new compounds possess marked anticonvulsant properties and, in analogy to 1, antagonize seizures induced by AMPA. In addition, when compared to the model compound 1, compounds 3 show a longer-lasting anticonvulsant activity and a lower toxicity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789358
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