Title of article
Azepinoindole derivatives with high affinity for brain dopamine and serotonin receptors
Author/Authors
Bruce E. Maryanoff، نويسنده , , David F. McComsey، نويسنده , , Gregory E. Martin، نويسنده , , Richard P. Shank، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
983
To page
988
Abstract
We synthesized 20 and 21 as conformationally constrained analogues of the dopamine receptor antagonist SKF-83742, as well as analogues 6–9, 16, and 18–22. Although 20 and 21 were inactive, 7, 9, and 19 showed strong binding to D-1, D-2, S-2, and α-1 receptors, as well as antipsychotic activity in vivo.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789361
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