Author/Authors :
Manuel Norte، نويسنده , , JoséJ. Fern?ndez، نويسنده , , Mar?a L. Souto، نويسنده , , JoséA. Gav?n، نويسنده , , Mar?a L. Candenas، نويسنده , , Pilar Ausina، نويسنده ,
Abstract :
A complexation study was carried out with okadaic acid (OA) and the univalent metal ions Li+, Na+ and K+, and the divalent metal ions Ca2+ and Mg2+. K+ binding was observed identical with a complex obtained from the natural source (OAC). The pharmacological trials demonstrated that this cation has a very important influence on the pharmacological activity of okadaic acid.
