Title of article
PF1022A — A novel anthelmintic cyclooctadepsipeptide. Modification and exchange of the N-methyl leucine residues
Author/Authors
Jürgen Scherkenbeck، نويسنده , , Achim Harder، نويسنده , , Andrew Plant، نويسنده , , Hubert Dyker، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
1035
To page
1040
Abstract
The first structure-activity relationships of the anthelmintic cyclooctadepsipeptide PF1022A have been established via a systematic exchange of the leucine residues by a series of related N-alkylated amino acids. The data presented strongly suggest that (L)-N-methyl-leucine is crucial for high in vivo activity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789371
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