Title of article
Anti-HIV pronucleotides: Decomposition pathways and correlation with biological activities
Author/Authors
D. Egron، نويسنده , , I. LEFEBVRE-TOURNIER، نويسنده , , C. PERIGAUD، نويسنده , , Maria T. Beltran، نويسنده , , A. Pompon، نويسنده , , G. Gosselin، نويسنده , , A. -M. Aubertin، نويسنده , , J. -L. Imbach، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
1045
To page
1050
Abstract
The purpose of the present study was to compare the decomposition pathways in CEM cell extracts of various phenyl phosphoramidate derivatives of AZT. In addition, the structures of their metabolites were identified. Correlations with their anti-HIV activities in a thymidine kinase deficient (TK) CEM cell line have been established with a rationale of designing phosphoramidate pronucleotides capable of delivering intracellularly their respective 5′-nucleoside monophosphate derivatives.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789373
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